This week, Dr. Christopher Shade joins me to talk about detox in a way that actually makes sense. Instead of jumping straight into protocols or pushing things out too fast, we break down how detox really works in the body and why drainage has to come first.

We discuss what happens when toxins build up, how they move through the liver, kidneys, and lymph, and why symptoms like fatigue, brain fog, skin issues, and reactivity often point back to a system that isn’t draining well. We also get into why stress, inflammation, and even hormone shifts can slow detox down, keeping you stuck.

We also walk through binders, how they actually work, why different types matter, and how to use them in a way that supports your body instead of overwhelming it. This episode helps you think about detox in a more practical, step-by-step way so you can stop guessing and actually make progress.

KEY TAKEAWAYS:
• Detox starts with drainage
• Pushing too fast = feeling worse
• Liver, kidneys, lymph all matter
• Stress shuts detox down
• Not all toxins act the same
• Binders help you clear, not recirculate
• Skin issues can be detox overload
• Histamine = overwhelmed system
• Start slow, build up 👍 

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ABOUT GUEST:
Christopher Shade, PhD, founder and CEO of Quicksilver Scientific, continues to be a driving force of development and innovation in Functional and Integrative Medicine, creating high-efficacy detoxification systems for wellness and longevity by employing high-bioavailability delivery systems for nutraceuticals and whole-plant extracts.

WHERE TO FIND GUEST:
Website: https://www.quicksilverscientific.com/
Instagram: https://www.instagram.com/quicksilverscientific/ 
Instagram: https://www.instagram.com/dr.christophershade/

WHERE TO FIND CHRISTA:
Website: https://www.christabiegler.com/
Instagram: @anti.inflammatory.nutritionist
Podcast Instagram: @lessstressedlife
YouTube: https://www.youtube.com/@lessstressedlife
More Links + Quizzes: https://www.christabiegler.com/links
Protocols: https://www.christabiegler.com/protocolshop

SPONSOR:
Thank you to Jigsaw Health for being such a great sponsor. 😎 Use code LESSSTRESSED10 anytime for 10% off!

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TRANSCRIPT:

[00:00:00] Christopher Shade, PhD: When they all come up. You get more reactive too, 'cause it lowers glutathione levels. When glutathione levels go down, you shift over to the more reactive state. That's why when the toxic load is high, you're more reactive. So when metals which are dragging down glutathione are high, you're more reactive.

[00:00:17] Christa Biegler, RD: I'm your host Christa Biegler, and I'm going to guess we have at least one thing in common that we're both in pursuit of a less stress life. On the show, I'll be interviewing experts and sharing clinical pearls from my years of practice to support high performing health savvy women in pursuit of abundance and a less stressed life.

One of my beliefs is that we always have options for getting the results we want. So let's see what's out there together. 

All right. Today on the less stress life we have back Dr. Christopher Shade, who is founder and CEO of Quicksilver Scientific and continues to be a driving force of development and innovation in the functional and integrative medicine space. Quicksilver creates high efficacy detox systems for wellness and longevity by employing a high bioavailability delivery system for nutraceuticals and whole plant extracts.

This is the kind of bio I like 'cause it's got a lot of big words and I also like to talk in big words. So I always, we've done a couple episodes, I think we did one on nano particulate form particle size and I can't remember the other one. I'd have to look. It's in our nerdy, we have a special, we have a different playlist for different topics and I think they're probably both in our nerdy, I 

[00:01:46] Christopher Shade, PhD: get the nerdy, 

[00:01:47] Christa Biegler, RD: I think you're probably on the nerdy playlist.

I can't quite remember. So 

[00:01:51] Christopher Shade, PhD: yeah. 

[00:01:52] Christa Biegler, RD: Yeah. So you must have some new things coming out or something because we actually had reached out to you, but then you ended up as a pitch in our inbox. So we'll find out whatever that is. Later, I'm gonna ask you what else is new and exciting and what you're working on these days.

But I told you before we hit record, I don't think we've heard your story of how it says Chris Shade nearly killed himself following the pro prevailing detox dogma. He removed all 17. Someone else wrote this part, all 17 Mercury amalgams in one sitting took massive chelation doses and realized that they were doing things wrong.

So after this plus chronic Lyme plus it says a good LSD trip, let environmental chemist Dr. Shade and reinvent a new detox medal model. Sorry. So I'm like, I don't know if I've heard this story. So tell us a little bit about your Mercury story. What happened when you got 17 amalgams taken out? Because I could see how this would be a little bit of a stress on the body if done.

[00:02:49] Christopher Shade, PhD: Yeah. I don't know about, almost killed myself. The PR people, they're like a little, in fact, especially mine, and she'll pull stuff across and she's amp that word a little bit, but definitely damage myself, that's for sure. And I think the almost killed himself story and we'll go back to all this, but while I was in the.

Thick of all this mercury coming out. My brain was so fried, I drove right to this one red light, and I remember this big pickups truck just like screeching to the hall then like careening around me. And I was like, that's probably did almost kill myself there. But yeah, I. I did my PhD and I was working on environmental mercury toxicology and testing tiny amounts of mercury in the environment.

Nanograms, picograms and nanograms. A millionth of a milligram picograms. A billionth of a milligram. And then you're looking at a buildup in like insects and little fish, and we're all worried about this. And then we got, a couple of grams of mercury amalgam in our mouth, and I remember saying to one of my thesis advisors what about this guy's?

Eh, we've been doing it for a long time and there's no better alternatives. There was at least 30 different alternatives at the time. And just because we started doing it in 1870, because that seemed like a good thing to do, then does not mean we should be doing it now. And I had this experience along the way where I was like, I recognized how much of this mercury was just dripping down my mouth and you're swallowing, it's all going through your GI, just felt the metal just pulling on me and I'll say, it wasn't that resilient then.

I was young, my kids would get sick, I'd get sick, I'd go travel, and lecture. I'd get sick and adrenals were just tired all the time and I started my company, we were doing testing around Mercury, originally in environment, but I wanted to go over to clinical. And so I went over to clinical and functional integrative medicine.

It's really integrative medicine then. And I'm like, oh, we can apply the testing here. What do you guys do? And they're like we do these challenge tests. We take these chelators and you pee out mercury, and then you'll be able to see if it's from fish or from amalgams. I'm like, great, let's do it.

I have 17 amalgams. I start taking these chelators for a challenge test and I'm like, yeah, there's not much mercury coming out. And I feel crappy afterward. First I feel good, then I feel crappy, and I'm like these amalgams are bad. I know it I met this guy who takes 'em out and he offered to do it for free for me.

If I just did it all in one sitting, it's all 17 or just swept right out. And then I'm like, okay. And now I take the chelators. And so I didn't do anything to open up drainage pads, kidney, lymph, nothing on liver and clearing gi all the stuff that we do for detox now. And so I get 'em all out. I start taking the DMSA and I'm measuring my urine and it's barely anything's coming out. And I'm like I must have to take more. And so I start taking more until I'm taking like a gram and a half per day and my energy just crushes and crumbles. I drive through the red light, I'm going to these functional medicine meetings and I'm watching these luminaries, talk about GI and liver and the microbiome and how it responds to poisons and microbes.

And I'm watching all this and I'm just getting tireder and sicker. And it was a couple of weeks of watching this. So really it was over like two, three months. And I was like, wait a second. I shouldn't be pushing this all through the kidneys. I should be pulling it through the liver, gi, and clearing all that mercury out from there.

And so I ended up making what's now IMD, it's a binder specifically for heavy metals and it's got massive ability to bind mercury. It can buy 20% of itself in mercury. It's one little hundred milligram spoon of this is equivalent to like 70 chlorella tablets.

And so I made this stuff. I just had this vision that I should do this because something similar was done in poisoning in Iraq in 1973. And I said to myself, I have a better version of this. I've already made it for taking mercury out of water, either for cleaning it up or for analysis. And I'm like, I have the right thing for this.

So I made it. I started taking capsules of it, whole bunch of it, cleared myself up, in a couple of weeks, and these people were seeing me at these functional medicine meetings. Were like, what did you do? We thought you were gonna die. And now you're like on top of the world. So taking the amalgams out, not having any plan, not having any drainage open, not having any of the detox chemistry up and going and forcing the chelators in there, just recirculates everything.

And when they talk about a Herxheimer reaction, it's. Not a true Herxheimer reaction, which is a reaction to endotoxin of the body from killing off too much bacteria at once. When we talk about it, it's a negative detox reaction. I was like the worst of the herxheimer's. And by opening up what this GI chelator did was start pulling off the mercury from around the GI layer and that opens up the gates up to the liver to dump more in.

There's like a feedback system, like I ain't dumping more in there, it's already poisoned. And so this just sucked the stuff through, bound it, and then you poop it out. And that opened up everything. And then from there I started understanding really drainage pathways in the liver and the kid with knees.

I understood how to upregulate the cell's, ability to dump mercury in and feed it into this draining system and got myself all better and built what we built today. 

[00:08:39] Christa Biegler, RD: Yeah, okay. IMD is like a heavy dose of silica, right? Silica is really mercury, so 

[00:08:45] Christopher Shade, PhD: no, it's silica is the carrier for it. And then there are bound onto it, covalently bound onto it.

Imagine a little sand grain, but it's like a popcorn almost. It's a blown up sand grain that's got all this surface area all over it. These are called silica gels and they're designed to have surface area to bind things if the silicon combined it. But on that surface area, you can put a specific chemistry and it's called a thiol chemistry.

Thiol are these reduced sulfur groups the same as you would have on the DMSA or DMPS chelator or on glutathione. So now picture that little exploded silica with tons of hairs coming off of it with thiols on the end, so you chemically modify it to be specific for mercury. That's why it can take up so much mer here.

[00:09:34] Christa Biegler, RD: Okay. And I think you have a binder that I wanna talk all about, binder ingredients, but I feel like I should wait until we talk a little bit about drainage and I wanna talk a little bit about big picture drainage, detox testing issues around it. And then I wanna come back to the sensitive version of the binder you have.

'cause I think we should carry here 

[00:09:51] Christopher Shade, PhD: doesn't, because some people it like triggers things in 'em 

[00:09:56] Christa Biegler, RD: because they're struggling with their sulfur metabolism. Would that be it?

[00:09:59] Christopher Shade, PhD: We don't really know. In fact, there's so much total amount of sulfur in the clays and stuff in there that it really doesn't make sense that sulfur make sense.

But everybody thinks sulfur is all the same. And sulfur is like neutral sulfur Is that yellow powder? Oxidized sulfur are like sulfate, like magnesium sulfate. 

[00:10:19] Christa Biegler, RD: That 

usually works 

[00:10:20] Christopher Shade, PhD: fine. EP and salt VAs, but it doesn't bind anything. But it's bind on the body. Yeah. Then sulfite, which is a preservative, is irritating to the body.

And then over on the reduced side, you have all these sulfur compounds that are in garlic and these isothiocyanates, those are irritating through the sulfur metabolism. And then you have the thiols, which. Sometimes they're irritating, sometimes aren't, but this isn't even getting absorbed. So it's something that happens in the GI of some people where you know, and I made this for Joe Carnahan was like, oh, I react to that and some of my patients do.

So we made the sensitive and they were fine with that. So the Ultra binder has lots of different binders in it and the IMD, but IMD on its own. We sell in these professional detox kits so people can put more and more of the IMD in it. And then the ultra binder sensitive doesn't have the IMD in it.

[00:11:16] Christa Biegler, RD: Yeah. I'm gonna just call IMD I'm just gonna call that the popcorn silica for the surface area. Yes. That's the picture I'm gonna have in my brain. Okay. So we'll come back to, binder products, and I think that's funny that you made that for Dr. Jill. It helps when you live in the same place and you can do this.

[00:11:31] Christopher Shade, PhD: Yeah. She's 

[00:11:32] Christa Biegler, RD: close by miles 

[00:11:32] Christopher Shade, PhD: away. 

[00:11:33] Christa Biegler, RD: Yeah. Yeah. 

[00:11:33] Christopher Shade, PhD: Awesome. Come we work on stuff. 

[00:11:35] Christa Biegler, RD: Yeah. That's fun. Okay, so I wanna talk a little bit about something that your story sorts of alludes to a little bit. I think that with drainage and detox, we don't have any alternative. I don't think we have an alternative besides education awareness of what this looks like in the body first, because I always say our testing for this is not.

Amazing. Like you can't just go in and be like, oh, am I detoxing? It's like there's a lot of like offshoot things. Like for example, mercury, you have this very detailed mercury test, right? But that's unless you're going to seek that out, and you're certainly not gonna get that at your doctor's office.

So this is the issue is we all need to understand the skill and be good at detoxification, otherwise we can have a million symptoms. And maybe we can talk a little, like you talked about being really foggy in the brain. 

[00:12:23] Christopher Shade, PhD: Yeah. 

[00:12:23] Christa Biegler, RD: There can be fatigue. For me, it's fatigue. I'm not like, I don't have good energy.

Also if my detox is jammed, if I drink coffee, I'll get like heart racing. Which makes some sense, right? Physiologically. But these things that people wouldn't really think right all the time. Anytime you got skin stuff, there's a detox thing. But the thing is like at some point you get to learn this in some way.

Maybe you're sensitive to smells, maybe. But if you don't, there's not like a good test. You're gonna go in and someone's gonna validate this and give you X, Y, z antidote. I just wanted to point out, we have an issue with testing for detoxification and drainage problems. People have to believe in the physiology, like the basic science of the body, right?

You have to be able to see oh, I seem to have a lot of symptoms in this. 'cause there's a lot of toxicants. You brought up mercury already and we could talk about any kinds of metals. That one's for me, like not something I. Play around a lot with, I see an absurd amount of mold, right? But all the dysbiosis or bacterial, any kind of fungal, bacterial, et cetera, all of those things give off their own waste as well.

So anytime you have in general gut stuff, whether you have symptoms of gut stuff or not, all of that has its own. Byproduct. And so you have all of this stuff adding up what's, 

[00:13:35] Christopher Shade, PhD: yeah, they have poisons and they make inflammation, which opens up the gut lining. And you get endotoxin, which are little pieces of those bacteria and that are winding up, inflammation, winding up neuroinflammation.

And when you wind up inflammation that shuts down detox. When you wind up neurological neuroinflammation, that puts you into a sympathetic dominance. It activates the glutamate transporters. And that's what's happening when you have too much coffee or any kind of stress that's shutting down detox too.

And a lot of we're gonna be doing a webinar with Jason Earl on new paradigms in understanding mold. A lot of the mold is a neurologic sensitivity. When you smell it and it's even sub sensory and you have a neurological reaction, which. Propagates into your immune system and you have inflammation run up from that, and that blocks detox.

And if you're smelling things and reacting to it, that's a neuro excitatory path that's blocking detox. So there's a lot of ways that we're shutting it down. And so we look at kidney drainage and liver drainage. There are some, if your creatinine clearance is low, that's bad on our urine to blood ratio for the mercury.

If you get that test, you can see that if you are known to have gallbladder problems, you know your drainage is bad. So if you have a sludge of gallbladder or gallstones, or if you had your gallbladder removed, they take them out really easily. Because you've got buildup in there. If you're from a family that has that kind of thing.

If you have lipase and amylase high in your blood, you know that drainage is wrong. But you may not have, or you may not ever have been diagnosed with sludgy gallbladder or anybody looked at it. And any of those things we talked about before, inflammatory, toxic neuro activators, all slow down liver drainage and in fact even estrogen dominance slows down liver drainage.

And of course any sympathetic, you're in fight or flight, not rest, digest, repair, regenerate, detoxify. And so all that is blocking. So it's yeah, what are we doing for drainage? Bitters? YL choline, calming down, breathing for the liver, kidneys, just diuretics, dandelions, stuff like that.

Boom. Boom. 

[00:16:04] Christa Biegler, RD: I'm smiling because you brought up one, does anyone not have gallstones? Sometimes after you're in this for all, you're like, I believe everyone has this to an extent, but you brought up estrogen, so something, I am gonna go die on this hill. And maybe you're pretty much like this too, is you gotta learn the skills of drainage and detox, in my opinion.

You gotta learn the skills of taking care of your stress hormone chemistry. Yeah. I think like those are foundational to everything else functioning. For example, thyroid your thyroid's just not gonna work if your drainage isn't working or your stress hormone. If your adrenal suck.

[00:16:35] Christopher Shade, PhD: That's why the energy goes down as the thyroid is poisoned and the mitochondria are poisoned and you just go and your energy goes down.

And so it's. Draining all these poisons, bringings those back in. And like you said, the neurologic, you said the stress hormone component. When you're controlling that and you're controlling stress, drainage naturally opens up more and healing all opens up more, which is why mindfulness and breathing all has great total body effects.

GI work always has whole body g effects because of bringing down the endotoxemia and the dysbiotic toxins. 

[00:17:15] Christa Biegler, RD: Yeah. I wanna make sure we drill in on the science of stress work for drainage. You we're bringing it up a little bit before, but before we go there, let's talk about increased estrogen, taxing the detoxification, because I am.

I'm probably getting fed this as well, 'cause I'm about that age of perimenopause. But for me, I feel like perimenopause is this hot topic, right? And perimenopause is called, I don't know if it was Laura Bryden or who calls it second, or if it's one of the other big women's health people, but they call second puberty, right?

Because estrogen actually rises during that time. And so people see a lot of increase in histamine symptoms, et cetera. And I think to myself, when I hear about these things, I'm like. Isn't this, just going back to exacerbation of drainage issues. Isn't this just going back upstream? Like even if your estrogen is increased, you still need to, there can be some top level reasons.

It can be higher, it might be alcohol can that may be a factor. Even if you don't 

[00:18:10] Christopher Shade, PhD: do anything. 

[00:18:11] Christa Biegler, RD: Yeah, 

[00:18:11] Christopher Shade, PhD: it's going to, you 

[00:18:12] Christa Biegler, RD: still need to improve your drainage. What 

[00:18:14] Christopher Shade, PhD: hap in Perry progesterone you're two opposite workers in there. It's not estrogen, testosterone, it's estrogen and progesterone and estro.

What happens in Perry? Progesterone starts going down and estrogen starts wildly swinging. It's not always up. It could be really high. I remember testing my ex-wife and one day she was 250 and like a couple weeks later she was 15. And so it swings up high and it's not balanced by progesterone.

That's when it activates these things. Estrogen in the brain activates the glutamate receptors. It's a glutamate receptor agonist, which winds up what anxiety, irritability, sympathetic dominance against whenever you're on that side, your fight or flight. So you shut down detox. Now, progesterone on the other hand, works as a gaba receptor agonist and calms everything down and opens up drainage.

And so like even during pregnancy, there's cholestasis of pregnancy when estrogen gets too high. So estrogen has a direct reso action on the bile system, slowing it down when it's high and unopposed by progesterone. And then it has the secondary compositing effect on the neurotransmitter balance by activating too much glutamate activity.

And that's why it winds up and that shuts down bile flow two. 

[00:19:48] Christa Biegler, RD: Gosh, hard decision on whether we go now to bile flow and system or back to specifically what happens with drainage. I think let's go back to specifically some of the mechanisms that happen with drain drainage. 

[00:19:59] Christopher Shade, PhD: Yeah, that's your drainage of the liver is bile, 

[00:20:01] Christa Biegler, RD: right?

But let's talk about how stress specifically, or doing or improving stress or how stress specifically shuts down drainage. You brought it up a little bit earlier with the neuro inflammation, but let's talk more about that. 

[00:20:13] Christopher Shade, PhD: Yeah. So we just said that estrogen, unposed, and excessive works on the glutamate receptors when glutamate is overactive and not balanced by gaba.

And it's not that you even make more glutamate, you get hypersensitized receptors that are overactive. That puts you into sympathetic dominance, which shuts down the bile flow because we don't need to digest. That's why I like you go get a massage or acupuncture, you're in parasympathetic, you come out, you're hungry.

So anything that puts you in the sympathetic autonomic dominance is shutting down bio flow. And so yeah, estrogen can do that, but stress hormones are doing that. The. Reaction of stress does that itself. It's putting you in fight or flight and shutting off these regenerative, anywhere from eating to draining mechanisms.

And it's real direct and real simple. That's why stress kills 'cause not just the bile flow and making more toxins, but it's shutting off regenerative healing biology. 

[00:21:15] Christa Biegler, RD: So let's talk a little bit about toxins being stored in the fat, and as you start to pull them out, what is the step-by-step process your body goes through.

And it's part of what I'm thinking about is when we usually talk about drainage, we're talking about, a lot of times we're mostly talking about lymphatics and what's going on with the liver. But kidneys don't always, I know you make some kidney products, you've mentioned kidneys a little bit. How much are things going through the kidneys?

I worked in kidney care for a long time and I feel like the liver is quite regenerative. It does take six months for some of those cells to recycle, but it seems like, it feels like the kidneys is, they're 

[00:21:48] Christopher Shade, PhD: delicate. 

[00:21:49] Christa Biegler, RD: more delicate. Yes. Yes. The, and that the glo eye are so much more delicate and so it worries me a bit.

[00:21:54] Christopher Shade, PhD: That was where I saw, don't push the metals to the kidney. You're gonna destroy him. Mercola talks openly about this. He wrecked his kidneys doing too much DNPS. So the liver, we call it the starfish organ, you can cut 30 or is it 60% of the liver away, and it'll regenerate. It regenerates fast, so does the GI lining.

That's why I moved over to using liver and gi. The kidneys are very slow to regenerate. These are like seven year cycles, not for all the cells, but really rebuilding everything and they're really prone. Just like liver can get fibrotic cirrhosis, kidneys are prone to fibrotic interstitium the area between the nephrons, but the kidneys, like classic drainage, old European drainage chemistry is kidney, liver, lymph, it's always been there, but we now tend to talk more on the liver and lymph side.

And lymph is a very physical drainage thing. Whenever you do. Do kidney work. It does help you drain more, but it's movement and rotational movements and walking and swinging the arms and massage as some of these direct lymphatic drainage, either massage or these electrical techniques.

All those open up lymph flow. Now, one of the things, you open up lymph flow, but you don't have kidney and liver open. What happens after a massage when you're pretty toxic? You actually feel worse. You come out of there foggy. And that's why I try to sell binders to massage therapists, binders and bitters.

at least give 'em binders. After you move all this, they'll say, drink a lot of water. That's to help flush the stuff out. For different toxins, some will go. Specifically liver. Some will go specifically kidney, some will go both. So in the Mercury case, methylmercury specifically goes through the liver, the bile, and GI a lot.

Once it gets to the gi, it reabsorbs. So that's a case where you need binders, inorganic mercury. The salt form that you get from your amalgams goes roughly 50 50 between kidney and liver. And if one is blocked up, disproportionately more go through the other. And so we're not just detoxing mercury, that was my big thing.

You're going in there with this chelator and you're going after. Mercury and a couple other metals. What about everything else you have? That's why you want to open up the drainage and open up the system and feed the whole system. So everything's going out. And if you want to feed something specific over the top of that, you can do that then.

But that's, drainage is job number one. 

I wanna address something else you said, because it's a misunderstanding. We put all the toxins into fat fat soluble toxins. Go into the fat 'cause that's where they partition into.

And so PCBs and polyaromatic, hydrocarbons and flame retardants, they're going into the fat. Then people think mercury goes into the fat, but mercury binds on the thiol groups, which are part of proteins. So mercury goes and heavy metals go into the protein areas. Some of them substitute for things like calcium, like lead and go into the bones.

Cadmium goes some into the bones, but you have like tons of thiol, chemistry and organs like the thyroid. So a lot of mercury ca arsenic end up in thyroid in the proteins. And so toxins are in lots of different compartments according to the nature of their chemistry. 

[00:25:31] Christa Biegler, RD: Oh, that is really interesting. That makes me wonder so it's not that many people that I've had that were able, that were aware of this, that were reacting to sulfur compound.

They would say sulfur compounds and supplements specifically, and we talked about this a little bit. I feel like usually the people that I did have had mold history, but it makes me wonder if they also had some metal issues because am I associating dial with sulfur properly? 

[00:25:57] Christopher Shade, PhD: Yeah, you are. Those are specific ths are a specific kind of highly reduced sulfur that you find on cysteine that gets incorporated into proteins.

And then they're also in these iron sulfur clusters, a couple of different enzymes that are high concentration in these organs, glandular organs. And so a lot of metals go into those areas. It's not that there isn't a lot of toxins and fat, and that's a big thing with being people being on GLP ones.

They start breaking down a lot of fat, such a good point, and globalizing a ton of toxins. All of a sudden they're losing their hair. Is it because they're malnourished? 'cause they're not eating or because of the toxins. And during keto, people go into keto, they get the keto flu we found during the big keto days, you give them binders and all of a sudden there's no keto flu because they're mobilizing and stuff.

And you open up drainage and binding and things get. Better. But yeah the metals can produce sulfur sensitivities. People have genetics, CBS mutations that make them more likely to have those or suox sulfate oxidase mutations. And that's where they're breaking down these weird sulfur to sulfate and it gets stopped at sulfate and then they're reacting to the sulfate.

Histamines will come up a lot from that. And then they need something like molybdenum to help the enzyme get through to sulfate. Molybdenum for all the sulfur issues is one of your go-tos. But early on we're working a lot with the chronic disease group and the cling heart people and stuff. And I remember being in sitting next to Dietrich Klinghardt listening to this guy talk and we were both like raise the hand like, Hey, people are doing way too much kale smoothie and cabbage and garlic and stuff, thinking that was sulfur are.

Are going to detoxify them, but instead they're reacting to them and blocking detoxification. And as a point towards type of sulfur versus total sulfur we said to this guy who represented all these chronically ill people, which do you feel better on a steak or a piece of chicken or a bowl of cabbage?

And they're all like, oh my God, the steak, you know the protein, we feel great on that. Guess what? There's about 10 times more total sulfur in your protein than there is in your cabbage. But the type in there is really irritating. So in that time, both Dietrich and I and other people were bringing people off of using all this garlic and onion and all this stuff, all of a sudden they're feeling much better.

And then you give them an atil, cysteine or glutathione, they don't react to those, and all of a sudden everybody's starting to get better fast. 

[00:28:40] Christa Biegler, RD: Yeah, there's a lot to unpack there. I always enjoy chatting about the people who are sensitive to very specific things.

And then my thought is if you get a lot of the trash cleared out, you become a lot less sensitive to everything. 

[00:28:54] Christopher Shade, PhD: A lot less sensitive. 

[00:28:55] Christa Biegler, RD: That's what I find. But the tricky thing is with these metals if I was gonna do a mercury test, I probably infl, that was probably our other episode that we did, I bet, was about Mercury once upon a time.

I don't remember. It was a while ago, but 

[00:29:09] Christopher Shade, PhD: I think, so 

[00:29:09] Christa Biegler, RD: I the default to the tritest because it's tissue, it's blood, it's urine blood. 

[00:29:15] Christopher Shade, PhD: Urine 

[00:29:16] Christa Biegler, RD: blood, her and urine. Thank you. But. With these other metals. I feel like you can it's sticky stuff a little bit because it sounds like with our old, I call it the old version maybe it's still really common.

The old version was chelation and it sounds like that does push straight to the kidneys instead of Yeah. The liver. And it always, like everyone, people would always talk about like how they felt really bad. I was like, I'm not gonna touch that with a 10 foot pole. That always seemed concerning and I've always done fine.

[00:29:44] Christopher Shade, PhD: And you go our path, open up drainage, upregulate the glutathione system, feed glutathione in, have all the binders. You'll get rid of everything. And the thing is, you feel better. Almost right away. You might need to titrate up your doses, but you're getting better right away.

The chelator thing, like the Cutler crowd was the most famous in this. 

[00:30:05] Christa Biegler, RD: Yeah. 

[00:30:05] Christopher Shade, PhD: And they thought I was a murderer because of how I didn't use their method. But their method got me in a lot of other people sick. And they would say themselves for the first 50 cycles, that's a year. You're gonna feel worse.

And I'm like, nah, man, three months I'm gonna have you feeling great and you're gonna keep going. 

[00:30:24] Christa Biegler, RD: Yeah. I don't really get into the, if you'll feel way worse before you feel better, which I know you don't either, because you're like, we shouldn't be having big hercs reactions. Now if you go on some stuff and you're not on enough binder, it can happen.

But it just it's also a good, it's a good experience to say oh, sometimes that's the tricky part about binders is you didn't know how bad you could have felt without 'em. 

[00:30:44] Christopher Shade, PhD: Yeah, 

[00:30:44] Christa Biegler, RD: potentially. 

[00:30:45] Christopher Shade, PhD: Yeah. And say the liver has been moving slowly for a long time. We have to open up and get it really rolling.

Kidneys are moving slow. We gotta open up and getting it really rolling. And if we're mobilizing at the same time, maybe they're not ready to clear that fast. So there's a balance between mobilizing from the tissues into the blood and draining through liver, kidney, and then you can use skin to help as well.

And then there's genetic snips where there's only so fast you can go. So it's really, you get into it at a certain dose. If you're feeling good, roll for a while up the dose and keep rolling. If you get into it and you're feeling a little crappy, maybe you'll get over it in two days. Maybe it, you'll still feel just drop the dose.

[00:31:29] Christa Biegler, RD: Yeah, 

[00:31:29] Christopher Shade, PhD: go for that while it's all opening up and then raise the dose and that's the way to go. 

[00:31:36] Christa Biegler, RD: I wanna talk about binder ingredients, but first I'll share, I work with a lot of skin and I will share that humans don't like anything looking, speaking of looking worse, right? Yeah.

Binders absolutely help with that. 

[00:31:48] Christopher Shade, PhD: Yeah. 

[00:31:48] Christa Biegler, RD: But if we overdo things too early, which I think bile mover, even though we wanna move bile, if we're overdoing it, I start with bidders. But if we're all, if we're doing it with something. I think choline is quite a bit more of a heady hitter. It usually throws things on the skin if you do it too soon, if you haven't reduced the overall toxic load.

That's my experience. That's my opinion. Based on the binders we can talk about that. You 

[00:32:11] Christopher Shade, PhD: can. No choline, is gonna work on a cellular level two building up membranes. And the membranes might then be moving. The a hundred percent I see it all the time is when there's too much going to the liver.

The liver can't dump to the bile. And then what happens is the liver opens up a door back into the blood. And that's when the load, it accumulates and it dumps it all. That's when it goes to the skin. Yeah. And it's not because you have too much bile going, it's because whatever you're doing is mobilizing faster than it's dumping bile.

Yeah. Or you're not binding and it's coming back out. Yeah. But it's generally, I think this is when people jump into a bunch of lipoic acid and it mobilizes from the tissues, but the liver's not open to take it, then it goes to the skin.

[00:33:03] Christa Biegler, RD: I find both cases are correct on, there's still too much toxic burden.

It's just like too much. Yeah, too soon 

[00:33:09] Christopher Shade, PhD: you 

can wait 

[00:33:10] Christa Biegler, RD: a month 

[00:33:10] Christopher Shade, PhD: or two. Open up drainage binding, so there's toxic burden in the tissues. There's compartments, so there's the tissues are more like static and stored. And then there's the blood compartment and then there's going out through drainage.

And when you're more symptomatic in going through skin and stuff, it's usually there's too much in the blood. So if you open up liver drainage and kidney drainage and have the binders, but you're not putting in glutathione, you're not putting in NRF two up regulators, certainly no chelators lippo acid, big NRF two up regulator.

And time you do that, you mobilize some tissue. So first just drain, get the load in the blood down, and then you can mobilize from tissues. 

[00:33:56] Christa Biegler, RD: Yeah. Yeah. I find that even doing like membrane mend for some people, if they do have, and I think part of it, and this is we have really put a cap on this, , there's a lot of people who have toxin exposure, that they don't know about or in denial about, and that's what you don't really have a lot of problems. Trying to do anything is 'cause 

[00:34:14] Christopher Shade, PhD: Are you saying even doing membrane mends? Like without a 

[00:34:17] Christa Biegler, RD: Sometimes it'll push things out to this. 

[00:34:19] Christopher Shade, PhD: Yeah. 

[00:34:20] Christa Biegler, RD: Makes sense though. 

[00:34:21] Christopher Shade, PhD: It's 

[00:34:21] Christa Biegler, RD: reasonable. 

[00:34:22] Christopher Shade, PhD: The tuka. Bitters are more specific to the liver.

Syl choline is a big part in membrane bend is a big part of bio flow, but it's also affecting all the membranes. Yeah. And helping them mobilize toxins. Yeah. And then it's got, tocotrienols and astaxanthin in it. Yeah. That may mobilize some. 

[00:34:45] Christa Biegler, RD: I think it's an awesome product. And I always say does this make sense?

Yeah. With the physiology that's in front of us. Yes, it makes sense. 'cause your body's pouring stuff on the skin and we're trying not to let anything get poured on the skin. And you're right, because the second part is are you getting enough binders or the right kind? And I think this is the perfect segue into types of binders.

So I do reference a lot. Vibrant has a really nice chart that has all their evidence of different types of binders. But I do really send me charcoal. And I know that a lot of these different binders have a lot of different things, clay and CU light, et cetera. And I wanna talk about some of these different ingredients.

They don't all bind to things like we talked earlier about the popcorn. Silica doing a beautiful job for Mercury, but for some people maybe it's throwing off. In general, you can also get the one that doesn't. Let's talk about the ingredients of binders, how you've arrived at some of these ingredients for binders.

The bottom line is all binders I use really need to be taken except for straight up fiber. Which I is a later thing anyway because charcoal is much more effective earlier. They all need to be taken away from food and supplements to be effective, but as you can imagine that makes them slightly annoying.

And so sometimes people may skip them sometimes or the other issue is people, sometimes we say, go to bowel tolerance. And sell, you're constipated. And then we have to back off a little bit. So let's talk a little bit about these ingredients for binders, how you've arrived at some of these.

'cause you have a few different formulations. Yep. And so it's I'm a huge fan of like how it works. How did you decide on some of these things? Yeah. What has been your experience about them, et cetera? 

[00:36:19] Christopher Shade, PhD: Yeah. Like we said before, the toxins go into compartments according to their chemical nature.

Binders attract toxins that have a chemical nature that. Is good for binding to them. And so the different, it's not like there's one binder that gets everything the most. Universals probably activated charcoal, but it's really not strong on metals. So activated carbon or charcoal gets a whole bunch of stuff.

And in mold, toxins, there's a bunch that bind really well to the carbon and a bunch that bind really well to a clay matrix. The clay matrix has a different type of absorption and is really good on other things. And then you have bentonite versus zeolite. Zeolite is just a very fancy clay that has a lot of absorptive capacity.

Some people try to acid break it down into little chunks that'll go into your body, and I don't like doing that. So we have. Charcoal in there. We have a little bentonite. We have a bunch of zeolite. Kaizan is a certain chemistry comes from shellfish, but it's an allergic. It's been de cyl related, so it doesn't have the shellfish protein nature to it, and it's chemically very similar.

To well call or cholestyramine. And so it's really good at biotoxins like mold, toxins and if you're in the, Florida or near the water, there's a lot of toxic algal blooms that have volatiles that come out. There's other volatiles, from mold that the tizen is very good at.

And so you've got all those binders in there. And then IMD specific for metals, a half dose in there. So you've got all this binding and then you have things in there that are helping the gi like a Casey gum. Casey Gum, gum. Arabic is very good for the GI lining. It's a slow probiotic and Arab galactan that feeds bifidobacteria.

Bifido are one of the main ones that you're trying to feed and they help break down endotoxin, so we'll have that in there. We might have a modified citrus pectin. Modified citrus pectin has been used as a binder. It's not a very strong binder, but it's a very good immunomodulator and brings down inflammation in the gut.

And guess what happens when you bring down inflammation? You detox better. And so that's what will be in ultra binder. And then the different formulations. One is IMD, one doesn't, the capsules have a little bit more pectin and less of the Acacia gum. If you're trying the binders, you try the capsules.

Capsules are great for ease and travel, but if you take the raw powder with all the acacia gum and mix it up in water, put a little shaker and drink it down, it's immediately soothing and it's a better binder. But the capsules, chemically work very well. And often it's the only thing that people will do.

We started, we doubled or tripled our cell of binders by just having capsules. 

[00:39:34] Christa Biegler, RD: I know I always like to have both options. I prefer. I always tell people I like powder because in your head you can take an actual good, solid, effective dose in powder and you don't really notice it. Like people mentally, they're like, oh, if I have several capsules here, it's a lot.

Oh, I swallow 

[00:39:54] Christopher Shade, PhD: please. 

[00:39:54] Christa Biegler, RD: Yeah, exactly. So they're like, oh, I'm taking, and every once in a while I catch someone like taking almost no binder. Yeah. They're like taking one capsule. It's that's not really gonna do anything 

[00:40:03] Christopher Shade, PhD: looking there. They'll be like there's six, six is a big number. And I learned this with my mother-in-law.

I was giving her this, c lipoic and glutathione and she'd have to take 10 total pumps and she'd be like, 10 is too many. So I mixed them together in a bottle and I had her take a teaspoon and one was a good number. And so 

[00:40:24] Christa Biegler, RD: I know this is why the 

[00:40:26] Christopher Shade, PhD: medical teaspoon is six capsules one. 

[00:40:28] Christa Biegler, RD: I know that's 

[00:40:29] Christopher Shade, PhD: teaspoons four.

So a take one. 

[00:40:31] Christa Biegler, RD: Yeah, I know. This is where medically they have us on the functional integrative space because it's here take one dose for 24 hours and we can't get it quite like that here. Yeah. Like you're gonna need to take more and more often. 

[00:40:44] Christopher Shade, PhD: Yeah. 

[00:40:44] Christa Biegler, RD: But, we get a really good outcome.

But I think it's really good to point this out. I think like you have to intermix the humanity of Oh yeah. Like sometimes people are just like not taking 

[00:40:54] Christopher Shade, PhD: an 

[00:40:54] Christa Biegler, RD: effect. I find people like, don't take effective doses all the time, so Yeah. I think 

[00:40:57] Christopher Shade, PhD: I'm very minimalist. I used to make real big protocols and some of my clinical people love big protocols and the guys who do it all get great results, but so many people won't do that.

And 

[00:41:08] Christa Biegler, RD: well, and it's at this point, like there's a lot of overwhelm. And it was one of my sales points is like, how can we do, and it's a game for me. It's like, how can we do more with the least? And so that's like what, and you can do that if you rotate through. 'cause you're, like you said, one thing isn't going to take care of everything.

If you can find some unicorns that do a lot, that's great. And that's our goal is to find things. 

[00:41:28] Christopher Shade, PhD: Sauce is actually four products in one bottle. 

[00:41:31] Christa Biegler, RD: Oh, tell me more about how it's four products in one bottle and how you arrived at that too. I think this is fun. 

[00:41:36] Christopher Shade, PhD: It's bitter X, it's histo aid. It's nano milk thistle.

[00:41:42] Christa Biegler, RD: I dunno, it hist. 

[00:41:43] Christopher Shade, PhD: Then it's lipoic acid. 

[00:41:45] Christa Biegler, RD: Oh, nice. I didn't know it had, 

[00:41:47] Christopher Shade, PhD: yeah. So the bitters is there for the bile flow. The histo aid is there to calm the mast cells while you're moving toxins so you don't wind up inflammation and block that. And it also, they help also with AMPK and NRF two, the milk thistle's there because it's big liver heavy hitter.

And the lipoic acid is there as a big NRF two up regulator to get your cells to dump stuff. So all the programs are in there. Tissue dump, bile flow, immune control, and liver support. 

[00:42:21] Christa Biegler, RD: Tell me what goes in the original histo aid, because I wanna talk also about, it's a good segue. I wanna talk a little bit about the explosion of histamine issues since COVID happened.

[00:42:34] Christopher Shade, PhD: Oh, interesting. Yeah, so Histo aid is cetin and Ludi Olin as the drivers for mast cell stabilization. It has dim, which shifts we talked about when we're toxically burdened. We're much more reactive 'cause your immune system shifts over to TH two, TH 17 dominance, which is non-specific inflammation, just going, ah, sound, the alarm.

It's very allergic. TH one is very search and destroy and so dims. And then T regulatory is, let's just not freak out. Let's be peaceful here. Dim switches you more to T regulatory. It's immuno tolerant. While, like I said, of course in luteal and are mast cell stabilizers, and there's a little vitamin C in there, which is a co-factor for metabolizing histamines once they're released.

So that works very quickly. If you're reacting to something, in 10, 15 minutes you've calmed everything down. Now it goes away quick, and within two hours is gone. So you may have to reapply it, but often you're just going and stopping the propagation of these inflammatory reactions and then you're cool.

Now post COVID, why? Is mast cell activation so much higher now. And this has gotta be shifts in the immune system that are happening during COVID or from vaccination where your immune system is more on high alert and more reactive. And, even with traditional vaccines will put adjuvants in there that make you more reactive.

And so I think that's what's happening. Spike protein might be part of that. It's a serious irritation to the immune system. So I think it's just the immune system spazzes out a lot more. And then because the immune system's hyper-focused on COVID, then you upregulate like all these stealth viruses, herpes family, cytomegalovirus, Epstein Barr, they all come up.

When they all come up. You get more reactive too, 'cause it lowers glutathione levels. When glutathione levels go down, you shift over to the more reactive state. That's why when the toxic load is high, you're more reactive. So when metals which are dragging down glutathione are high, you're more reactive.

So I think there's this couple things going on with the immune system and both right at it. And then secondarily from these other infections that pop up behind it. 

[00:45:05] Christa Biegler, RD: Yeah, for a long time I was noticing some things that I didn't realize everyone was noticing. I just stopped going to conferences perhaps.

I'm not sure what it was, but for a long time I thought, oh if you already are not really at an optimal place with your systems, and then COVID comes in, inputs all this inflammation which uses up a lot of nutrients, et cetera. Now you're really incapable of eliminating things, right?

Yeah. And you become sensitive to things that you may not have had issues with before. 'cause you're not clearing out the waste, you don't have the workers to clear it out 'cause you've used up all these nutrients. I think that can be a true mechanism. I think that there's probably many mechanisms. I was giggling when you were talking 'cause you were talking about the immune system freak.

Like being hypervigilant and freaking out. Yeah. And whatever. And I was like, are you talking about the immune system or the stress response? Chris? I It's a joke. 'cause they could be one and the same. 

[00:45:52] Christopher Shade, PhD: They're totally dovetailed. 

[00:45:54] Christa Biegler, RD: Yeah, 

[00:45:54] Christopher Shade, PhD: totally. And when COVID hit, the people with low glutathione hit way harder.

The people with low NAD were hit way harder. And that's why glutathione and NAD were the biggest rescuers for people who are in exaggerated inflammatory responses. And yeah, a lowered system is gonna have more of a hit to the inflammatory process and more of one that just keeps going. 

[00:46:19] Christa Biegler, RD: Yeah. I wonder if, you would think I would know this at this point being, it's like with the perimenopause, estrogen complaint, histamine complaint, I'm why don't we just improve our histamine metabolism?

So that's like still my thought is like why don't we just improve the histamine metabolism and function? 

[00:46:33] Christopher Shade, PhD: Yeah. Yeah. Lu the company, I dunno if maybe it was biotics, they, one of their biggest products ever was selling you the enzyme that breaks down histamine. 

[00:46:43] Christa Biegler, RD: I know, I think that's unfortunate.

I think we could do better than that, in my opinion. It's fine if that's what you wanna do. I just think could better. Yeah. I'm saying it's a way to 

[00:46:51] Christopher Shade, PhD: go in and help. 

[00:46:52] Christa Biegler, RD: It isn't a good way to do it. I know they used to be. It's funny though, like that used to be almost impossible to find. And they, it used to be, what was the company called?

It was a random, it was a company that also sold like a product that broke down kidney stones. I tried to interview someone from the company. I knew someone who consulted for them. I dunno even what happened to the company. 'cause for there was a time in practice where I would use that. I just, as you try to get to less products, you're like, why don't we just go instead of giving you the enzyme, why don't we help you actually break it down?

So whatever. 

[00:47:22] Christopher Shade, PhD: What do you do for increasing histamine metabolism? 

[00:47:25] Christa Biegler, RD: Improve what's going on in the gut function, improve what's going on in the gut function, and clear out the drainage so that way it can be metabolized through generally. Some people might genetically have slow DAO and HNMT.

Me too. I definitely do, but I definitely I think that. These systems just get overwhelmed. I mean it's, I think of it like this. I think of it the same as like you can take digestive enzymes and that's fine and you will get good results. I just prefer having bitters because then you're helping what I saw, literally even as limited as our testing is and it was very dramatic for me when I saw this the first time.

I would get, give people enzymes to get fine results. 'cause everyone sucks at digesting. But I saw on some testing the digestive enzyme markers like so high it didn't make sense. And I learned it was, there was a cultural thing happening where the person was eating a bunch of bitters after meals.

And I was like, and it changed my whole perspective on that for a 

[00:48:20] Christopher Shade, PhD: lot of people reported that they stopped using enzymes and they just used bitters and they got much better response. 

[00:48:26] Christa Biegler, RD: And it makes sense. 

[00:48:27] Christopher Shade, PhD: Yeah, it's totally 

[00:48:28] Christa Biegler, RD: a Swiss army knife. I think. Bile function. 

[00:48:30] Christopher Shade, PhD: Yeah. It does so much for you and I think when you're approaching increasing histamine metabolism by doing gut work well, you're also decreasing the toxic irritation on the mast cells and the activity of the mast cells.

So it's a little hard to de devolve them. Yeah. But you're systemically improving. 

[00:48:50] Christa Biegler, RD: Yeah. 

[00:48:51] Christopher Shade, PhD: Their overactive histamine response and their metabolism at the Yeah. 

[00:48:55] Christa Biegler, RD: And it's like what we get to, we have a whole platter of options and we can only choose a few, and it's I wanna choose the one where I have to be on less supplements longer term.

Because you can just be on something that, we'll call it mast cell stabilizer and these, and to that point, things like the ingredients in histo aid can be life changing and life improving for people, especially when they're in stress of it. And I love that. I didn't realize that. I love that's a combination in liver sauce, because I think especially as we're doing that work, sometimes you need more of that.

I think that's totally fine. The goal is how can I be on the least things with the maximum impact? Yeah. Always. Yeah. So that's what I'm looking for. Okay. Couple more questions on just sensitivities to things. You brought this up earlier. But since, we're having some nerdy conversations about chemistry and forms of things, and you alluded to it slightly earlier, but there's often been a little bit of, it's a quiet complaint now that I hear where people talk about being sensitive to glutathione, due to glutamate issues, et cetera.

And what would you say to that?

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[00:52:00] Christopher Shade, PhD: I would say we don't know why certain people are sensitive to glutathione. I've not seen, yeah, glutathione is made out of glutamate, glycine and cysteine, but you have ton of glutamate. It's not like you're taking in raw glutamate till you break the glutathione down.

And so I haven't, with other people who use a lot of glutathione other glutathione companies, we've talked about this and I can't totally find what the source of that is. How Huggins used to talk about that a lot and IVs never doing more than 250 milligrams when people are doing three grams.

Certain people have it and I don't totally know you can give them molybdenum. See if that helps. You can start at really low doses. That usually helps quite a bit. But it's hard to get the mechanism. 

[00:52:54] Christa Biegler, RD: Yeah. I was thinking about this earlier, but I forgot to ask. I've had a couple people that swear that they're sensitive to the aloe in some binders and I'm wondering if you have any comments on that.

I haven't been able to 

[00:53:06] Christopher Shade, PhD: come up with a reason, so you can't I don't remember which ones don't have allo. I think the capsules do not. I have to look, but the regular ultra binder and sensitive both have dried aloe at like 1% or less. It's a pretty small amount. It was just to help soothe. 'cause aloe is so good for you building the GI lining, but it's not a lot.

[00:53:30] Christa Biegler, RD: Yeah. And you would think it should assist with the constipating properties of binders. 

[00:53:34] Christopher Shade, PhD: Yeah. And that was part of it is to be a laxative as well. The strongest laxative is magnesium hydroxide or magnesium oxide. These aren't magnesium sources for the body. They're just draw water down to the body, caric acid.

Helps with that magnesium ascorbate. So there's a lot of different ways to go with that. And the allo was in there for soothing and stopping constipation, but it's not, you have to be really hypersensitive to it for that to be, 

[00:54:02] Christa Biegler, RD: yeah. I don't know why I can't come up with, because I'm a questioner in general, so I don't really like when we're sensitive to things.

So I'm always like why would we even be sensitive to that thing? But sometimes I know this is the case with at least one, sometimes we're on other medications and then we have these other things that happen downstream of that as well. And 

[00:54:18] Christopher Shade, PhD: yeah, we don't really, 

[00:54:19] Christa Biegler, RD: yeah. Yeah. So I'm not sure, but just curious if you had any thoughts on that.

I to start to wrap this up. 

[00:54:26] Christopher Shade, PhD: Yeah. 

[00:54:27] Christa Biegler, RD: With a bow, we were talking earlier at the very beginning and how. I think you have to just understand that you need to support drainage and detox and a lot of the conversations we have go back upstream to that, in my opinion. And probably your opinion as well, knowing your line of work.

And so the thing is, and like it's wonderful if you can take inventory of symptoms and see an improvement afterwards. And I especially think of, and I think this is gonna be great 'cause you're a man. And I get, most of my clients are females. Not all, but most. And I always have this joke about men being less aware, less self-aware, less yeah, just mostly less aware.

And when you don't have good awareness of symptoms, sometimes it's hard to make shifts around things. 'cause it's like you have to wait for something to get horrible before you improve it type thing. And so it's interesting, it's what if someone is doing some detox work and they are having a hard time telling the difference, right?

Or what would you say to these, maybe wives that wanna help their husbands, but they're like I don't feel any different. I'm just curious and I don't really necessarily care what the answer is either here, but I don't know. It just popped into my head and I was like, I can't wait to see what you think about this thing.

[00:55:32] Christopher Shade, PhD: You're wondering specifically the feelings that people have when 

[00:55:38] Christa Biegler, RD: yeah. So what if you don't feel any difference after you're doing some detox work, let's say you don't have a physical, or even in my realm, when we're working on skin stuff, it can take some time for that to improve.

But let's pretend someone says, oh, I don't feel different when I'm doing detox work. And it's this is where I think awareness. You have to do a symptom inventories first, so you have something to measure. And I find usually with men, you have to give them to that on a silver platter, typically 

[00:56:00] Christopher Shade, PhD: a hundred percent rate these things and you ask 'em to do it again later.

Don't even let 'em think about the questionnaire till later and you're gonna see the change. Some people are very insensitive to the changes in their body. They're insensitive to feeling how toxic they are. They're insensitive to feeling that they become less toxic, or the rate of change was so slow they didn't notice it.

Or there's something overriding that's usually a chronic infection that's making 'em feel bad, worse than the toxins. So even though you're getting toxins out, these infections are making it worse. And when you have a chronic infection, that tends to block detox. So you're not getting so much out. And then the last is when they're not actually taking the product, but they're 

[00:56:50] Christa Biegler, RD: Sure.

Yeah. No, those are good points. And you had Lyme? Yes. Was the Lyme also right around the mercury and the toxic burden time or was it after? 'cause you find sometimes this stuff all gets wrapped up together. 

[00:57:01] Christopher Shade, PhD: I'm a east coaster. I'm from Pennsylvania. I really literally used to go to a beach and body surf on this beach on Plum Island.

If you know what Plum Island is, you know what Lyme, Connecticut is? Lyme Connecticut is where the first cases of LY were found, which is the first place population center on shore from Plumb Island where the military biologic space was, where they developed Borrelia Borg I, where Willie Borg fer, the German Nazi scientist we brought over was doing that work.

[00:57:42] Christa Biegler, RD: Oh, I didn't realize that. 

[00:57:43] Christopher Shade, PhD: Yeah, no, it's that's what happened. 

[00:57:46] Christa Biegler, RD: We've been doing biological warfare for a lot longer than I realized. 

[00:57:49] Christopher Shade, PhD: Yeah. According to him, it was developed. They were gonna drop ticks outta airplanes and just waste out the soldiers so they couldn't fight. And, yeah, I was exposed to a lot of Lyme, and I think I had it chronically for a long time.

It might have been when I went back on vacation up to the Adirondacks and I got bid or something, but I had all the Lyme and the co-infections and the viruses and all that different stuff. That was after I'd done all the Mercury detox. So I think there was, that was. Holding on me, was in there in the background.

And Lyme, a lot of us view it like herpes virus, like it's in there and it activates, it deactivates, it hides. And it was after working a lot, having a lot of stress, a lot of travel. The Lyme really wound up. And then I figured out that it was there and treated it. And oh my god, my life was vastly better after that.

So it, you can have like background infections and still detox, or the infections could be so bad. They're blocking detox or they're blocking they're the main drivers in your in your mitochondrial dysfunction, not the toxins. And so if they're not feeling anything, either symptom question before and after, they're insensitive, or there's a larger driver that's usually infective that's dominating the malaise and keeping them from feeling better.

[00:59:16] Christa Biegler, RD: Yeah. Yeah, we have some episodes online and issues around testing and trying to find it long term. Yeah it's a tricky thing. Did you end up doing antibiotics or did you use herbals? 

[00:59:26] Christopher Shade, PhD: No I built crypto Comax and Liposomal Crypto Le Lepus. Those are the biggest ones for that. Calo Vmax is our biggest one for viruses, so I did all herbals.

I didn't do any antibiotics. 

[00:59:40] Christa Biegler, RD: Yeah. Cool. I do the crypto lepus. That reminds me, I do get people, especially like if there's mold stuff, they'll react negatively to cat's claw as well. But I think that, I don't know, I find that people with mold stuff, as you start mobilizing it will have viral stuff.

They'll have herpes stuff like pop up. That makes sense because their immune system is getting suppressed overall. 

[00:59:58] Christopher Shade, PhD: Yeah. And the is very strong and going in small doses and bringing it up, but make sure you have the big animals like the Lyme out of the way and parasites are a huge one.

And those are the top of the immune. They're at the top of the big organism pyramid and they're one of the big immunosuppressants. But Lyme's a huge immunosuppressant too. So if you're like trying to kill the viruses, but the Lyme and the parasites are in there, all your hyperactivity is gotta be there and you're not gonna get right.

[01:00:30] Christa Biegler, RD: Yeah, viruses are secondary. That makes a lot of sense. What are you working on right now or what's exciting to you or what's been new in your world that you've worked on recently? 

[01:00:42] Christopher Shade, PhD: Peptides, we're doing oral liposomal peptides for everything we're talking about. PPC 1 57 with KPV is the biggest one for us.

K BPC 1 57 kind of rebuilds lots of stuff and turns up regeneration, especially in the gut lining. It's part of a protein that's formed in the stomach that's for modulating the gut lining repair. And so it's really good at that, but you can repair it. Then the next time you eat and inflame on something, you break it back down.

The KPV goes in and controls the inflammatory reactions and breaks the propagation of the inflammation. It also part of that propagation of inflammation is affecting receptors in your body. Things like growth hormone and other hormone receptors. So resolving the propagation of inflammation, stopping overactivity, and healing the gut.

This stuff is amazing and it stops a lot of the mast cell activation too. In fact, a lot of the doctors using the P-P-C-K-P-V said they stopped using chromin and other antihistamines 'cause they're stopping the immune propagation of inflammation. 

[01:01:53] Christa Biegler, RD: Yeah. Do you see right now you just have BPC 1 5 7 and KPV as a combo, 

[01:01:59] Christopher Shade, PhD: right?

No, we have 1 5 7 alone BPC with K-P-V-B-P-C with TB 500. We have copper gh, HK, both oral and topical as a skin. Serum. And we have epitol and thulin. And then for resetting the immune system, thym and epitol are fantastic. And those are really the big longevity ones. 

[01:02:23] Christa Biegler, RD: Yeah. 

[01:02:23] Christopher Shade, PhD: So B-P-C-K-P-V and then bringing in thym or thym and epitol is really gonna pull a lot of these troublesome cases forward.

[01:02:34] Christa Biegler, RD: Yeah, your really focus is immune stuff for the most part, which 

[01:02:37] Christopher Shade, PhD: makes sense now 

[01:02:38] Christa Biegler, RD: because that's always been that way. 

[01:02:40] Christopher Shade, PhD: Yeah. Is the immune dysfunction is both a cause and consequence 

[01:02:46] Christa Biegler, RD: Yeah. 

[01:02:46] Christopher Shade, PhD: Of the toxins and the infections and so the immune system having the wrong programs and being too inflammatory, it is causing a lot of these problems and.

Having the wrong focus is it's not killing, it's reacting. And so that's keeping the infections in. It's inflaming, that's keeping the toxins in. So resetting the immune response is huge. And the other new product that works into that whole immune response is ergot thee. Ergot thee is a composite product that's liposomal glutathione, liposomal vitamin C, a special selenium methyl cell and cysteine that's used for the enzymes for vitamin C and glutathione.

And then this super nutrient that's being proposed as an essential vitamin called. Ergo Thionine ergot. Thionine is a thiol based, almost like an amino acid that you have transporters for to bring into the blood. You have transporters in the cells. When you have damage to an organ, you upregulate transport into that activity where it regulates.

NRF two action and the glutathione system. And it lubricates between all your antioxidant systems. It's neuroprotective. It's cardioprotective, it's hepatoprotective, it builds with time. It's naturally in the food supply, but it's tends to be low in what we're eating. It's very high in certain mushrooms, including trumpet.

Mushrooms are called SEPs in Europe and oyster mushrooms, and that's part of why mushrooms have such a good benefit for you. So I never take liposomal glutathione itself anymore. I take ergo thee, which gives me all that stuff at once. And all of that, especially the ergot thionine, is settling to the immune system and pulls it away from these inflammaging type runaway non-specific inflammation.

Brings it back and has it do what it's supposed to do, which is go kill, inflame, come back and calm. 

[01:04:52] Christa Biegler, RD: Are you working on your anti-aging?

[01:04:54] Christopher Shade, PhD: Yes. 

[01:04:55] Christa Biegler, RD: Stuff. Yeah. 

[01:04:56] Christopher Shade, PhD: Yep. 

[01:04:57] Christa Biegler, RD: Yeah. So much to talk about with peptides, but I think you have to break it all apart because they have so many different indications and things as well.

So thank you for coming on today and chatting a lot about metal circulation sensitivities to things, binder types, post COVID, histamine, really stress on the drainage. I think that's important too. Where can people find you online? 

[01:05:19] Christopher Shade, PhD: Quicksilver scientific.com. Dr ade.com. On Instagram, there's Quick Source Scientific.

It's also on Facebook. It's on most of the socials but Dr. Christopher Shade on Instagram. It's also I'm on LinkedIn. These are all places that ones that are Dr. Che and Dr. Christopher Shade. Those are more me independently though of course, I'm talking about a lot of this stuff. And anything, Quicksilver is just all the quicksilver world.

[01:05:49] Christa Biegler, RD: Perfect. Thanks for so much for coming on today. 

[01:05:52] Christopher Shade, PhD: Thank you.